Q: Zyprexa & Son's Medical History
i have been diagnosed with bipolar disorder(mixed states) over ten
yrs ago and remember feeling it since i was nine. i have been stable and able to
maintain a job for over 12 yrs now. i take tegretol(mood stab) and lorazepam for
occasional sleep problems.
i'm having problems feeling really depressed lately,especially coping with the
fact that both of my, now adult, children have bipolar disorder and now my 13 yr
old grandson was recently diagnosed and on trileptal.
my main concern is my 31 yr old son, who has a significant medical history. 3
back surgeries, his colon removed, he has hep c, he also went into cardiac
arrest during one of his surgeries,and a recovering heroin addict. he
recently started going to mhmr,cause the mania got so bad.they prescribed him
zyprexa. he goes into such extreme manic states(he does not know what he is
doing)then he of course gets depressed, nonfunctioning. is this an ok med for
folks with any liver difficulties and/or hep c. guess i should be thinking about
my self, huh?
thanks for any information you may provide. sorry this is so long
Dear Linda --
Not long; understandable; and just like a mother to be asking help for her child
first. So, is Zyprexa a good mood stabilizer? looks like the answer
to that is a big yes, based on two recent studies which compared Zyprexa and
Depakote. One study was sponsored by the Zyprexa manufacturer and designed
in a way that slightly favors Zyprexa looking good; but one was sponsored by the
Depakote manufacturer. In both cases Zyprexa outperforms Depakote
significantly (we shouldn't forget about lithium, of course; there's a Depakote/lithium
head-to-head comparison underway in Britain currently). So, based on these
data and other studies which also show Zyprexa to be better than placebo, we can
pretty safely say at this point that Zyprexa is an effective mood
And, as you may have learned, it can bother people's
liver. So can Tegretol, of course; and Depakote. Lithium
doesn't. But, in your son's case, the way we would usually approach this
is to give the medication we really want to use for the bipolar disorder, then
watch his liver tests (simple blood tests) to see if his particular liver
is being bothered by that medication. If it was, we'd then be forced to
switch. Note that given your response to Tegretol, he might end up having
to look at the close Tegretol cousin called Trileptal, which is similar in most
respects except bothers livers much less.
Be cautious about letting anybody give you an
antidepressant now. Your worries might respond better to good
psychotherapy, if you can access that; that's a safer approach to take for
depression in someone with bipolar disorder.
And as you've probably told yourself many times, you
didn't pick your genes nor pick the ones which would get handed on.
Published January, 2003