Can Topomax Cause Bruising ...?
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Can Topomax Cause Bruising ...?

I have battled depression most of my adult life (I am 32), my question is about Topomax. Can Topomax cause bruising in the upper legs? I have had many bruises appear on my upper legs (thighs).  I don't think this is just from "spider veins". I take Wellbutrin and Effexor as well as the Topomax.

Dear Lisa -- 
Effexor could do that, as the serotonergic antidepressants (Effexor is part serotonergic/part noradrenergic, the latter meaning that it affects norepinephrine also) have been implicated in easy bleeding. Checking the "
prescribing information", the stuff the company has to report to the FDA and then make public, on Topomax: "thrombocyctopenia" is on the list, which means the little fragments of blood cells called platelets, which form blood clots, are too few in number. That can be associated with easy bleeding; its related but not the same as the serotonergic antidepressant problem, so in theory the two together could be causing a problem where neither alone could. Out of curiosity, I looked to see if "thrombocytopenia" might be on the Wellbutrin list, and sure enough, so now all three are candidates for causing this. Obviously now we want to know which one of the three was started right before this problem developed, perhaps; that would be an obvious clue where to look (so it must not be that obvious, or you'd not have written? Could be a tricky search; good luck figuring that out.)

Dr. Phelps

Published Sept., 2006


Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?