Drug Interaction w/Topamax & Glucophage?Topamax as a Mood Stabilizer?
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Drug Interaction w/Topamax & Glucophage?  Topamax as a Mood Stabilizer?

My doctor recently prescribed Topamax along with Lamictal to help with stabilizing my moods (I'm bipolar II). Why is Topamax not on your website as a mood stabilizer? Also, I have PCOS and therefore take glucophage, but have heard that this and the Topamax might not go well together. Do you know what the drug interaction may be?


Dear Amanda
Topamax is not on my website as a mood stabilizer because so far it has not been shown in "randomized trials" (those with a placebo "control" group) to work better than a placebo. It also has very significant side effects, although of course most of the medications we use as mood stabilizers do. In my view one of the only reasons it gets as much attention as it does, it's because of its frequent potential for causing weight loss. There are, however, some significant reports of improvement in patients with bipolar disorder taking Topamax, which are not to be ignored. If it did not so often cause cognitive impairment, I would probably use it quite a bit more.

As for an interaction between Topamax and Glucophage, I just ran those in a standard drug interaction checklist (
this one). It indicated no known interactions. I am not aware of any recognized interactions either. Someone might have been worried that the Topamax could inhibit appetite while the Glucophage was lowering blood sugar. However, Glucophage is well known not to lower blood sugar below normal levels. On the other hand, perhaps this might not be the case if you're not eating anything. As far as I know, that is the limit of the "interaction".

Dr. Phelps

Published March, 2007

Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?