Ryan's Story

EMAIL Ryan HERE
 

Six years ago, I had everything I could ever want—a happy marriage, a good job and we had just purchased our first home.  Amazingly and unfortunately, in less than a year that drastically changed.
 
I was a military public affairs officer in Texas.  My job required long hours and frequent, long trips away from home.  My first Southwest Asia deployment came on the heals of a four-month training stint on the East Coast.  That marked eight months of our second year of marriage spent apart. 


My wife had a very difficult time handling the time  apart.  She was often inconsolable.  Between work and trying to comfort her, I was under a lot of stress. At some point I became depressed.
 

Then while serving in the Saudi Arabia, I began to feel strange.  Everything difficult became easy.  A multitude of sounds, like the wind, fell into a rhythmic pattern.  Colors, light, numbers and language formed exhilaratingly intricate patterns intertwined by connections, or a common thread of meaning.  I was manic for the first time.
 
Despite embarrassing myself with overzealous, rambling emails, my illness managed to go unnoticed until I arrived home in Texas.  My wife noticed the change in me immediately and had me take a self-test for bipolar disorder.  I answered “yes” to almost every question, but yet I denied that there was anything wrong.  Still, I appeased her by going to the doctor.
 
There wasn’t a psychiatrist on the base, so I went to see a general practice physician. This was the worst mistake I made.  He could tell that I had been under a lot of stress and had been down, so he prescribed me Zoloft. The antidepressant sent my mania through the roof.  A couple of days later, at my protestation, I was hospitalized.
 
My first experience in a military hospital was a memorable one.  I was so paranoid that I thought I was part of a military experiment designed to test my loyalty and/or prepare me for advancement.  I thought doctors and the other patients were actors paid to represent abstract inner feelings of mine.
 

I was in psychosis.
 
I was treated with Ativan originally to calm me down, then Zyprexa or Olanzipine was added and Ativan was dropped.  It’s funny to me, I recall  writing a song praising Zyprexa while I was there.  Little did I know what problems it would cause for me.
 
I entered the hospital at 200 pounds.  Six weeks later I was 240.  Depakote was added to the Zyprexa shortly after leaving the hospital.  With the two weight-gaining drugs tag teaming me, I was nearly  300 pounds before the year was over.
 
 Worst of all, during my time in the hospital I was terrible to my wife. Psychosis caused me to believe that my wife and I were not meant to be together. The reality behind that was, I was bitter at her for sending me to the hospital when I had been so supportive of her.  She told me she would stand behind me no matter what.  I told her I wanted a divorce.   We separated.
 

In the months that followed discharge from the military, my thinking cleared enough that I realized I was making the biggest mistake of my life. But I could not convince her that the manic Ryan did not represent  my true feelings. We divorced in late 2000.
 
I went into a deep depression.  I returned home to the Midwest and immediately went back to work, but the depression and combination of Olanzipine  and Depakote dulled my mind and ruined my concentration.  I slept as much as 16 hours a day during that period, often not bothering to shower or shave before going to work.  For hours I would stare at my computer screen and accomplish nothing.
 
A new doctor led me to Lithium for the first time.  He slowly tapered me off both Olanzipine and Depakote, and in a short time I felt like a new man. I lost 80 pounds to begin approaching my old weight and I felt new energy and drive at the office.  Unfortunately, that proved too good to be  true.
 
By December of 2001, I was experiencing full-blown mania again.  The lithium had not been enough to cap my high moods and they bubbled over.  I was hospitalized for a third time.  Risperidone was added to my med regimen.
 
Over the next three years, we tried Quetiapine (Seroquel), Olanzipine again, Depakote again and Buspirone without success.  I continued to experience frequent manias with intermittent depression.  All told, I went through fourjobs in four different states in just a few years.  Finally, I moved home with my mother, and started going to the local VA hospital for treatment.
 
During that time, we have tried Ziprasidone (Geodon) and Topamax, both without success.  Only in the last few months have my moods stabilized for the first time on a combination of Lithium, Aripiprazole and Lamotrigine.
 
It’s been a long hard road.  After six hospitalizations, lost jobs and damaged relationships, it can take quite a toll on a person.  But I’m on a military pension now, and I have the opportunity and time to find something I want to do.  It’s an opportunity to find real meaning again.  I hope to resume my  career writing and  editing.

 

 

So I guess just to start, a little info about myself.  I’m 21 years old, about to start my senior year at MIT and am majoring in Materials Science and Engineering.  I’m currently doing a summer internship at a small pharmaceutical company outside of Boston working on a project in the field of transdermal drug delivery and living with a bunch of friends at an MIT fraternity.  I practice jiu-jitsu, play piano and saxophone, enjoy hiking, traveling, dancing, and riding horses.   

I spent the past year studying abroad at Cambridge University in the UK for which MIT has an exchange program with.  While I initially enjoyed the program, the winter became very tough for me and I found it very difficult to function at the normal level of academic and social ability that I usually have.  I also had lost a lot of spirit for life in general during that time period and I couldn’t understand why.  The depression lasted about 3 months and was dramatically released within a few days of traveling with friends around Europe during our spring break.  I was able to return to Cambridge, study quite effectively once more, enjoy my time with friends and felt much more confident for taking the monster end-of-the-year exams.  Then came a period where everything was even more elevated- I felt high about everything I was doing, had lots of abnormal energy, insomnia, loss of appetite, and a persistent feeling of adrenaline rushing through me, and things in my mind started getting a lot weirder.  I honestly thought it was something wrong with my endocrine system at the time and even had irrational fears of adrenal gland cancer which caused an intense panic attack, something I had never experienced before but for which my housemates called a paramedic.   

I went in to see a doctor in the UK  and in the 15 minute appointment after describing my symptoms she simply took a piece of paper, wrote down bipolar disorder, drew a sinusoidal curve and told me to go look up some useful websites.  To be honest, at that time I knew next to nothing about bipolar, only that it had something to do with your brain and that people who had it had difficult lives.  I was also pretty stigmatized and fearful of mental illness as well due to not knowing much about it.  That level of information definitely didn’t help during the depression that hit after the hypomania ended and during the time that I read through the first bits of info about bipolar that I found on the internet.   But fortunately, the period was short, I became well once more and I didn’t do anything I regretted.  I returned to MIT early to be formally diagnosed by the psychiatrists on campus who were much more gracious and professional with their treatment.  I spent another month after the diagnosis being well and not on medication but then another depressive episode started and I was prescribed lithium which I’ve been taking for about 2 months now.  Though I was quite fearful and reluctant at first to take it (as I had never been on serious prescription medication before as I had been blessed with excellent health throughout my life), I soon came to accept it and be quite thankful for it.  It honestly hasn’t been too bad for me- I realize that I am at a more mild level of the disorder at this point and that prognosis is much better if you start medication earlier.   

I’ve definitely educated myself much more about the disorder over the summer- have read Kay Jamison’s books and numerous websites- it’s amazing how much you can find out there just through Google.  After everything I have learned, in my case I do believe that having the disorder has greatly benefited me as an individual both in academics and in my personal life, and has given me a considerable amount of perspective and self knowledge that I didn’t have before.  I’m also much more driven to work in the field of pharmaceuticals- I was interested in them last summer when I worked for the same company and now I’m even more interested in them- have read some of the original papers on lithium and might consider doing a PhD later on in pharmaceutical chemistry or pharmacology depending on how things go.  I’d like to do anything I can to help myself and others who have this disorder.  It’s also been pretty engaging to approach the pharmaceutical industry with the combined perspective of scientist and patient.  Sometimes it does get pretty personal, especially at a small company.  The intern in the cubicle next to me is working on a project with co-crystals of carbamazepine (Tegretol) which improves the dissolution rate of the drug and may lead to increased bioavailability (how much of the ingested drug actually hits your system).  The other scientists working at the company are intensely brilliant, passionate, relatively young, love to have fun and are extremely dedicated to the life-saving nature of the products that they engineer.  I’m highly considering working there after graduation.   

I’m very lucky to have the family and friends that I do and a very good situation in life- it could have been so much worse for me if I was not this fortunate.  A number of my close friends were quite surprised when I informed them that I had manic-depressive illness as they never thought of me as particularly unstable and were under the common misconception that “nice people don’t get bipolar”.  Such is the nature of stigma.  It’s quite logical and understandable why stigma exists but its effects can be devastating.  However, I personally believe that a substantial amount of stigma can be reduced through education.  I never understood mental illness at all before I experienced it firsthand.  I also didn’t understand that depression (that is real depression) is an illness and that people can’t simply snap themselves out of it on their own will.   

I guess I’m still trying to figure out how I got into this whole new world and how I’m going to handle everything that comes my way but of course there is no choice but to tread this path.  It is always helpful and encouraging to know that there are others of my kind, that they have been through this as well and some of them have done some incredible things with their lives.  I am honored to be among you. 


  Email: istobias@mit.edu
 

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